New and Advanced Features of NONMEM 7 Workshop

15th February, 2018
Time: 08:30 - 17:30

Location: Doubletree by Hilton San Francisco Airport, 835 Airport Boulevard, Burlingame, CA 94010
Timezone: (GMT -5:00) Eastern Time (US & Canada), Bogota, Lima

Presenters: Robert Bauer, PhD; Brian Sadler, PhD, Indrajit Das, PhD

Course Objectives:

The objective of this course is to introduce advanced concepts of population pharmacokinetics in NONMEM. The course is targeted to individuals interested in solving population PK/PD problems using the new stochastic methods.  The course is for those who are familiar with classic NONMEM methods (first order (FO)/first order conditional estimation (FOCE)/Laplace), and are familiar with constructing control stream files.  Most of the course is instructional, with several hands-on examples for attendee participation    A thorough discussion of stochastic approximation expectation maximization (SAEM), Importance sampling (IMP), and Markov chain Monte Carlo Bayesian analysis (BAYES) will be presented, along with hands-on exercises.  After attending this course, the participant will know how to use advanced stochastic methods for analyzing population PK/PD data; structure the models into a MU-referencing format that will greatly increase the efficiency of the analyses; apply prior information from previous analyses to the present data; create population mixture models; create models for categorical data; use new abbreviated code features for easier modeling of inter-occasion variability; model additional mixed effects levels for grouping individuals, such as inter-clinical site variability; use the new DO loop feature in abbreviated code, such as for handling multiple bolus doses in transit compartment models that use the analytical absorption function.  Additional topics covered are: parallel computing and dynamic memory allocation for efficient memory usage; symbolic referencing to thetas, etas, and sigmas; Monte Carlo search algorithms to improve FOCE estimation; built-in individual weighted residuals; bootstrap tools for simulation; and greater control in average eta shrinkage calculations.  

View the Full Agenda

This course, the Beginners/Intermediate course, and the TMDD Lecture are part of one series. Interested parties may register for any combination of the four days, however if interested in the Beginners/Intermediate course those first two days are required to be taken together.

The fees for the course are as follows:

Industry - $800

Academia/Government - $700

Student - $600

**Group discounts available.**

Contact Lisa Wilhelm for more information.

Deadline for registration is:  February 9, 2018